RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-377
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
microRNA microarray; qPCR
Target
SOD2
Pathway
FOXO SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
Year
2008
Function
"miR-377 led to reduced expressions of p21-activated kinase and superoxide dismutase, which enhanced fibronectin protein production. Thus, overexpression of miR-377 in diabetic nephropathy indirectly leads to increased fibronectin protein production."